Position: Principle Scientist/Senior Scientist, Discovery Biology
Principle Scientist and Senior Scientist with expertise in in vitro/in vivo pharmacology in oncology and immune-oncology, will provide scientific leadership and expertise to support multiple immunoOncology projects. The candidate must be competent to interact with cross-functional discovery project team. The person should actively strengthen the cancer immunotherapy pipeline through championing internal projects and managing/supporting collaborations with external partners.
- Design, execute and interpret studies on the development of biologic (bispecific antibodies) immunomodulators and immunomodulator combinations for the treatment of cancer using in vitro and ex vivo human immunology experimental systems.
- Work in collaboration with other team members in designing human immunology models to test new immumodulators also being tested in murine and other animal model systems
- Analyzes complex issues significantly improves, changes or adapts existing methods and techniques.
- Develops research solutions that require extensive analysis and detailed investigation.
- Collaborate effectively with other colleagues across the global organization, as well as manage external collaborations with various industry partners
- Present scientific results to multidisciplinary teams and senior management
- Develops new ideas, concepts and approaches for immunotherapy and project workflow
- Keeps on the look-out, develops, and incorporates when needed new assay technologies or platforms to expedite the research and improve data quality, reliability, and predictive value when moving to later stages of early clinical development
- PhD degree in a relevant scientific field (e.g. immunology, inflammation, cancer immunology, oncology), with a 2-3 years of post-PhD experience either in an industrial and/or academic setting is preferred
- A strong background in human cellular (tumor) immunology and immune regulation, preferably in the area of cancer immunotherapy, as evidenced by peer reviewed publications in top-tier journals, would be an important asset for this position.
- Experience with in vitro and ex vivo platform for evaluating the human immune tumor microenvironment, including but not limited to utilization of isolated primary human tumor/immune cell assays, CART cells, tumor explants, human PBMC assays.
- Hands-on experiences in development and deployment of functional assays using human cellular systems for drug discovery in highly desirable.
- Ability to conceptualize new ideas for immunotherapy and research assay tools
- Familiarity with human and mouse tumor models and mechanisms of anti-tumor responses with strength in the analysis of the activity of human innate and adaptive cell populations and measuring anti-tumor effector lymphocyte responses
- Excellent interpersonal skills with the ability to interact effectively with people, internally and externally
- Team oriented work ethic and ability to work in cross-functional teams
- Outstanding presentation and interpersonal communication skills
- Ability to demonstrate effectiveness and growth in a fast-paced and dynamic team environment